Shipping out mek inhibitor resistance with shp2 inhibitors

Pedro Torres-Ayuso; John Brognard

doi:10.1158/2159-8290.CD-18-0915

Shipping out mek inhibitor resistance with shp2 inhibitors

Pedro Torres-Ayuso
, John Brognard

Surgery - General

Upstate Medical University

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

RAS is one of the most frequently altered oncogenes, yet RAS-driven tumors are largely refractory to anticancer therapies. Fedele and colleagues demonstrate that SHP2 inhibitors prevent adaptive MEK inhibitor resistance; therefore, combining MEK and SHP2 inhibitors represents an exciting new therapeutic approach for the treatment of RAS-driven cancers.

Original language	English
Pages (from-to)	1210-1212
Number of pages	3
Journal	Cancer Discovery
Volume	8
Issue number	10
DOIs	https://doi.org/10.1158/2159-8290.CD-18-0915
State	Published - Oct 2018

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title = "Shipping out mek inhibitor resistance with shp2 inhibitors",

abstract = "RAS is one of the most frequently altered oncogenes, yet RAS-driven tumors are largely refractory to anticancer therapies. Fedele and colleagues demonstrate that SHP2 inhibitors prevent adaptive MEK inhibitor resistance; therefore, combining MEK and SHP2 inhibitors represents an exciting new therapeutic approach for the treatment of RAS-driven cancers.",

author = "Pedro Torres-Ayuso and John Brognard",

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AU - Brognard, John

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N2 - RAS is one of the most frequently altered oncogenes, yet RAS-driven tumors are largely refractory to anticancer therapies. Fedele and colleagues demonstrate that SHP2 inhibitors prevent adaptive MEK inhibitor resistance; therefore, combining MEK and SHP2 inhibitors represents an exciting new therapeutic approach for the treatment of RAS-driven cancers.

AB - RAS is one of the most frequently altered oncogenes, yet RAS-driven tumors are largely refractory to anticancer therapies. Fedele and colleagues demonstrate that SHP2 inhibitors prevent adaptive MEK inhibitor resistance; therefore, combining MEK and SHP2 inhibitors represents an exciting new therapeutic approach for the treatment of RAS-driven cancers.

UR - https://www.scopus.com/pages/publications/85054399099

U2 - 10.1158/2159-8290.CD-18-0915

DO - 10.1158/2159-8290.CD-18-0915

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VL - 8

SP - 1210

EP - 1212

JO - Cancer Discovery

JF - Cancer Discovery

IS - 10

ER -

Shipping out mek inhibitor resistance with shp2 inhibitors

Abstract

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