Silicon as a potential uremic neurotoxin: Trace element analysis in patients with renal failure

Charles O. Hershey; Edmond S. Ricanati; Linda A. Hershey; Arthur W. Varnes; Patrick J.M. Lavin; William H. Strain

doi:10.1212/wnl.33.6.786

Silicon as a potential uremic neurotoxin: Trace element analysis in patients with renal failure

Charles O. Hershey
, Edmond S. Ricanati
, Linda A. Hershey
, Arthur W. Varnes
, Patrick J.M. Lavin
, William H. Strain

Medicine

University at Buffalo

Case Western Reserve University
Development Center

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We analyzed multiple trace elements in tap water, dialysis fluids, and CSF of patients on dialysis and with chronic renal insufficiency. Before placement of a deionizer in the dialysis unit, we found elevated levels of aluminum, barium, copper, silicon, and zinc in tap water and dialysis fluids. These were corrected by the deionizer. CSF silicon content was increased in patients with chronic renal insufficiency and on dialysis; CSF aluminum, barium, copper, and zinc were normal.

Original language	English
Pages (from-to)	786-789
Number of pages	4
Journal	Neurology
Volume	33
Issue number	6
DOIs	https://doi.org/10.1212/wnl.33.6.786
State	Published - Jun 1983

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title = "Silicon as a potential uremic neurotoxin: Trace element analysis in patients with renal failure",

abstract = "We analyzed multiple trace elements in tap water, dialysis fluids, and CSF of patients on dialysis and with chronic renal insufficiency. Before placement of a deionizer in the dialysis unit, we found elevated levels of aluminum, barium, copper, silicon, and zinc in tap water and dialysis fluids. These were corrected by the deionizer. CSF silicon content was increased in patients with chronic renal insufficiency and on dialysis; CSF aluminum, barium, copper, and zinc were normal.",

author = "Hershey, \{Charles O.\} and Ricanati, \{Edmond S.\} and Hershey, \{Linda A.\} and Varnes, \{Arthur W.\} and Lavin, \{Patrick J.M.\} and Strain, \{William H.\}",

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T2 - Trace element analysis in patients with renal failure

AU - Hershey, Charles O.

AU - Ricanati, Edmond S.

AU - Hershey, Linda A.

AU - Varnes, Arthur W.

AU - Lavin, Patrick J.M.

AU - Strain, William H.

PY - 1983/6

Y1 - 1983/6

N2 - We analyzed multiple trace elements in tap water, dialysis fluids, and CSF of patients on dialysis and with chronic renal insufficiency. Before placement of a deionizer in the dialysis unit, we found elevated levels of aluminum, barium, copper, silicon, and zinc in tap water and dialysis fluids. These were corrected by the deionizer. CSF silicon content was increased in patients with chronic renal insufficiency and on dialysis; CSF aluminum, barium, copper, and zinc were normal.

AB - We analyzed multiple trace elements in tap water, dialysis fluids, and CSF of patients on dialysis and with chronic renal insufficiency. Before placement of a deionizer in the dialysis unit, we found elevated levels of aluminum, barium, copper, silicon, and zinc in tap water and dialysis fluids. These were corrected by the deionizer. CSF silicon content was increased in patients with chronic renal insufficiency and on dialysis; CSF aluminum, barium, copper, and zinc were normal.

UR - https://www.scopus.com/pages/publications/0020582288

U2 - 10.1212/wnl.33.6.786

DO - 10.1212/wnl.33.6.786

M3 - Article

C2 - 6682524

SN - 0028-3878

VL - 33

SP - 786

EP - 789

JO - Neurology

JF - Neurology

IS - 6

ER -

Silicon as a potential uremic neurotoxin: Trace element analysis in patients with renal failure

Abstract

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