Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

Liguo Zhang; Xuelian He; Xuezhao Liu; Feng Zhang; L. Frank Huang; Andrew S. Potter; Lingli Xu; Wenhao Zhou; Tao Zheng; Zaili Luo; Kalen P. Berry; Allison Pribnow; Stephanie M. Smith; Christine Fuller; Blaise V. Jones; Maryam Fouladi; Rachid Drissi; Zeng Jie Yang; W. Clay Gustafson; Marc Remke; Scott L. Pomeroy; Emily J. Girard; James M. Olson; A. Sorana Morrissy; Maria C. Vladoiu; Jiao Zhang; Weidong Tian; Mei Xin; Michael D. Taylor; S. Steven Potter; Martine F. Roussel; William A. Weiss; Q. Richard Lu

doi:10.1016/j.ccell.2019.07.009

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

Liguo Zhang
, Xuelian He
, Xuezhao Liu
, Feng Zhang
, L. Frank Huang
, Andrew S. Potter
, Lingli Xu
, Wenhao Zhou
, Tao Zheng
, Zaili Luo
, Kalen P. Berry
, Allison Pribnow
, Stephanie M. Smith
, Christine Fuller
, Blaise V. Jones
, Maryam Fouladi
, Rachid Drissi
, Zeng Jie Yang
, W. Clay Gustafson
, Marc Remke

Scott L. Pomeroy, Emily J. Girard, James M. Olson, A. Sorana Morrissy, Maria C. Vladoiu, Jiao Zhang, Weidong Tian, Mei Xin, Michael D. Taylor, S. Steven Potter, Martine F. Roussel, William A. Weiss, Q. Richard Lu

Pathology

Upstate Medical University

Cincinnati Children's Hospital Medical Center
Sichuan University
Harvard University
Fudan University
Children’s Hospital of Fudan University
St. Jude Children Research Hospital
Temple University Health System
University of California at San Francisco
Heinrich Heine University Düsseldorf
University of Washington
University of Calgary
University of Toronto

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

Zhang et al. show that OLIG2⁺ progenitor cells drive Sonic Hedgehog subtype medulloblastoma (SHH-MB) tumorigenesis in mice and are enriched in recurrent or resistant patient SHH-MB. OLIG2 activates HIPPO and AURORA-A/MYCN signaling, and co-inhibition of these pathways arrests SHH-MB growth in mice.

Original language	English
Pages (from-to)	302-318.e7
Journal	Cancer Cell
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2019.07.009
State	Published - Sep 16 2019

Keywords

AURORA-A/MYCN
HIPPO-YAP/TAZ
OLIG2
OPC-like
glial progenitors
medulloblastomas
progenitor heterogeneity
recurrent tumors
single-cell transcriptomics
sonic hedgehog (SHH) signaling

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10.1016/j.ccell.2019.07.009

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Zhang, L., He, X., Liu, X., Zhang, F., Huang, L. F., Potter, A. S., Xu, L., Zhou, W., Zheng, T., Luo, Z., Berry, K. P., Pribnow, A., Smith, S. M., Fuller, C., Jones, B. V., Fouladi, M., Drissi, R., Yang, Z. J., Gustafson, W. C., ... Lu, Q. R. (2019). Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell, 36(3), 302-318.e7. https://doi.org/10.1016/j.ccell.2019.07.009

@article{85fc0fbdc6b14e36855f5e45ea49796e,

title = "Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse",

abstract = "Zhang et al. show that OLIG2+ progenitor cells drive Sonic Hedgehog subtype medulloblastoma (SHH-MB) tumorigenesis in mice and are enriched in recurrent or resistant patient SHH-MB. OLIG2 activates HIPPO and AURORA-A/MYCN signaling, and co-inhibition of these pathways arrests SHH-MB growth in mice.",

keywords = "AURORA-A/MYCN, HIPPO-YAP/TAZ, OLIG2, OPC-like, glial progenitors, medulloblastomas, progenitor heterogeneity, recurrent tumors, single-cell transcriptomics, sonic hedgehog (SHH) signaling",

author = "Liguo Zhang and Xuelian He and Xuezhao Liu and Feng Zhang and Huang, \{L. Frank\} and Potter, \{Andrew S.\} and Lingli Xu and Wenhao Zhou and Tao Zheng and Zaili Luo and Berry, \{Kalen P.\} and Allison Pribnow and Smith, \{Stephanie M.\} and Christine Fuller and Jones, \{Blaise V.\} and Maryam Fouladi and Rachid Drissi and Yang, \{Zeng Jie\} and Gustafson, \{W. Clay\} and Marc Remke and Pomeroy, \{Scott L.\} and Girard, \{Emily J.\} and Olson, \{James M.\} and Morrissy, \{A. Sorana\} and Vladoiu, \{Maria C.\} and Jiao Zhang and Weidong Tian and Mei Xin and Taylor, \{Michael D.\} and Potter, \{S. Steven\} and Roussel, \{Martine F.\} and Weiss, \{William A.\} and Lu, \{Q. Richard\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "16",

doi = "10.1016/j.ccell.2019.07.009",

language = "English",

volume = "36",

pages = "302--318.e7",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "3",

}

Zhang, L, He, X, Liu, X, Zhang, F, Huang, LF, Potter, AS, Xu, L, Zhou, W, Zheng, T, Luo, Z, Berry, KP, Pribnow, A, Smith, SM, Fuller, C, Jones, BV, Fouladi, M, Drissi, R, Yang, ZJ, Gustafson, WC, Remke, M, Pomeroy, SL, Girard, EJ, Olson, JM, Morrissy, AS, Vladoiu, MC, Zhang, J, Tian, W, Xin, M, Taylor, MD, Potter, SS, Roussel, MF, Weiss, WA & Lu, QR 2019, 'Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse', Cancer Cell, vol. 36, no. 3, pp. 302-318.e7. https://doi.org/10.1016/j.ccell.2019.07.009

TY - JOUR

T1 - Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

AU - Zhang, Liguo

AU - He, Xuelian

AU - Liu, Xuezhao

AU - Zhang, Feng

AU - Huang, L. Frank

AU - Potter, Andrew S.

AU - Xu, Lingli

AU - Zhou, Wenhao

AU - Zheng, Tao

AU - Luo, Zaili

AU - Berry, Kalen P.

AU - Pribnow, Allison

AU - Smith, Stephanie M.

AU - Fuller, Christine

AU - Jones, Blaise V.

AU - Fouladi, Maryam

AU - Drissi, Rachid

AU - Yang, Zeng Jie

AU - Gustafson, W. Clay

AU - Remke, Marc

AU - Pomeroy, Scott L.

AU - Girard, Emily J.

AU - Olson, James M.

AU - Morrissy, A. Sorana

AU - Vladoiu, Maria C.

AU - Zhang, Jiao

AU - Tian, Weidong

AU - Xin, Mei

AU - Taylor, Michael D.

AU - Potter, S. Steven

AU - Roussel, Martine F.

AU - Weiss, William A.

AU - Lu, Q. Richard

PY - 2019/9/16

Y1 - 2019/9/16

N2 - Zhang et al. show that OLIG2+ progenitor cells drive Sonic Hedgehog subtype medulloblastoma (SHH-MB) tumorigenesis in mice and are enriched in recurrent or resistant patient SHH-MB. OLIG2 activates HIPPO and AURORA-A/MYCN signaling, and co-inhibition of these pathways arrests SHH-MB growth in mice.

AB - Zhang et al. show that OLIG2+ progenitor cells drive Sonic Hedgehog subtype medulloblastoma (SHH-MB) tumorigenesis in mice and are enriched in recurrent or resistant patient SHH-MB. OLIG2 activates HIPPO and AURORA-A/MYCN signaling, and co-inhibition of these pathways arrests SHH-MB growth in mice.

KW - AURORA-A/MYCN

KW - HIPPO-YAP/TAZ

KW - OLIG2

KW - OPC-like

KW - glial progenitors

KW - medulloblastomas

KW - progenitor heterogeneity

KW - recurrent tumors

KW - single-cell transcriptomics

KW - sonic hedgehog (SHH) signaling

UR - https://www.scopus.com/pages/publications/85071933266

U2 - 10.1016/j.ccell.2019.07.009

DO - 10.1016/j.ccell.2019.07.009

M3 - Article

C2 - 31474569

SN - 1535-6108

VL - 36

SP - 302-318.e7

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

Abstract

Keywords

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