Small molecule derails translation initiation

Tatyana V. Pestova; Christopher U.T. Hellen

doi:10.1038/nchembio0406-176

Small molecule derails translation initiation

Cell / Cellular Biology and Anatomical Sciences

SUNY Downstate Health Sciences University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Eukaryotic initiation factor (elF) 4A plays an essential role in translation initiation on most eukaryotic m RNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited elF4A- and elF4A-dependent modes of translation initiation.

Original language	English
Pages (from-to)	176-177
Number of pages	2
Journal	Nature Chemical Biology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1038/nchembio0406-176
State	Published - Apr 2006

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title = "Small molecule derails translation initiation",

abstract = "Eukaryotic initiation factor (elF) 4A plays an essential role in translation initiation on most eukaryotic m RNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited elF4A- and elF4A-dependent modes of translation initiation.",

author = "Pestova, \{Tatyana V.\} and Hellen, \{Christopher U.T.\}",

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AB - Eukaryotic initiation factor (elF) 4A plays an essential role in translation initiation on most eukaryotic m RNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited elF4A- and elF4A-dependent modes of translation initiation.

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DO - 10.1038/nchembio0406-176

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JO - Nature Chemical Biology

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Small molecule derails translation initiation

Abstract

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