Smart "turn-on" magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles

Mehmet Veysel Yigit; Debapriya Mazumdar; Hee Kyung Kim; Jung Heon Lee; Boris Odintsov; Yi Lu

doi:10.1002/cbic.200700323

Smart "turn-on" magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles

Mehmet Veysel Yigit
, Debapriya Mazumdar
, Hee Kyung Kim
, Jung Heon Lee
, Boris Odintsov
, Yi Lu

Chemistry

University at Albany

University of Illinois at Urbana-Champaign

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

(Figure Presented) Smart agents. A contrast agent was designed by combining target specific nucleic-acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target-induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure).

Original language	English
Pages (from-to)	1675-1678
Number of pages	4
Journal	ChemBioChem
Volume	8
Issue number	14
DOIs	https://doi.org/10.1002/cbic.200700323
State	Published - Sep 24 2007

Keywords

Adenosine
Aptamers
Imaging agents
Magnetic resonance imaging
Nanostructures

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10.1002/cbic.200700323

Cite this

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abstract = "(Figure Presented) Smart agents. A contrast agent was designed by combining target specific nucleic-acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target-induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure).",

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AU - Yigit, Mehmet Veysel

AU - Mazumdar, Debapriya

AU - Kim, Hee Kyung

AU - Lee, Jung Heon

AU - Odintsov, Boris

AU - Lu, Yi

PY - 2007/9/24

Y1 - 2007/9/24

N2 - (Figure Presented) Smart agents. A contrast agent was designed by combining target specific nucleic-acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target-induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure).

AB - (Figure Presented) Smart agents. A contrast agent was designed by combining target specific nucleic-acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target-induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure).

KW - Adenosine

KW - Aptamers

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Nanostructures

UR - https://www.scopus.com/pages/publications/34948819141

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DO - 10.1002/cbic.200700323

M3 - Article

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ER -

Smart "turn-on" magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles

Abstract

Keywords

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