Somatostatin, somatostatin receptors, and pancreatic cancer

Min Li; William E. Fisher; Hee Joon Kim; Xiaoping Wang; Charles F. Brunicardi; Changyi Chen; Qizhi Yao

doi:10.1007/s00268-004-7814-5

Somatostatin, somatostatin receptors, and pancreatic cancer

Min Li
, William E. Fisher
, Hee Joon Kim
, Xiaoping Wang
, Charles F. Brunicardi
, Changyi Chen
, Qizhi Yao

Dean, College of Medicine

SUNY Downstate Health Sciences University

Houston Methodist
University of Texas Health Science Center at Houston

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.

Original language	English
Pages (from-to)	293-296
Number of pages	4
Journal	World Journal of Surgery
Volume	29
Issue number	3
DOIs	https://doi.org/10.1007/s00268-004-7814-5
State	Published - Mar 2005

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title = "Somatostatin, somatostatin receptors, and pancreatic cancer",

abstract = "Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.",

author = "Min Li and Fisher, \{William E.\} and Kim, \{Hee Joon\} and Xiaoping Wang and Brunicardi, \{Charles F.\} and Changyi Chen and Qizhi Yao",

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AU - Li, Min

AU - Fisher, William E.

AU - Kim, Hee Joon

AU - Wang, Xiaoping

AU - Brunicardi, Charles F.

AU - Chen, Changyi

AU - Yao, Qizhi

PY - 2005/3

Y1 - 2005/3

N2 - Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.

AB - Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.

UR - https://www.scopus.com/pages/publications/20044394224

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DO - 10.1007/s00268-004-7814-5

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SN - 0364-2313

VL - 29

SP - 293

EP - 296

JO - World Journal of Surgery

JF - World Journal of Surgery

IS - 3

ER -

Somatostatin, somatostatin receptors, and pancreatic cancer

Abstract

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