TY - CHAP
T1 - Sphingolipids and cardiovascular diseases
T2 - Lipoprotein metabolism, atherosclerosis and cardiomyopathy
AU - Jiang, Xian Cheng
AU - Goldberg, Ira J.
AU - Park, Tae Sik
PY - 2011
Y1 - 2011
N2 - Heart disease is widely believed to develop from two pathological processes. Circulating lipoproteins containing the nondegradable lipid, cholesterol, accumulate within the arterial wall and perhaps are oxidized to more toxic lipids. Both lipid accumulation and vascular reaction to the lipids lead to the gradual thickening of the vascular wall. A second major process that in some circumstances is a primary event is the development of a local inflammatory reaction. This might be a reaction to vessel wall injury that accompanies infections, immune disease, and perhaps diabetes and renal failure. In this chapter, we will focus on the relationship between de novo synthesis of sphingolipids and lipid metabolism, atherosclerosis, and cardiomyopathy.
AB - Heart disease is widely believed to develop from two pathological processes. Circulating lipoproteins containing the nondegradable lipid, cholesterol, accumulate within the arterial wall and perhaps are oxidized to more toxic lipids. Both lipid accumulation and vascular reaction to the lipids lead to the gradual thickening of the vascular wall. A second major process that in some circumstances is a primary event is the development of a local inflammatory reaction. This might be a reaction to vessel wall injury that accompanies infections, immune disease, and perhaps diabetes and renal failure. In this chapter, we will focus on the relationship between de novo synthesis of sphingolipids and lipid metabolism, atherosclerosis, and cardiomyopathy.
UR - https://www.scopus.com/pages/publications/80053604705
U2 - 10.1007/978-1-4614-0650-1_2
DO - 10.1007/978-1-4614-0650-1_2
M3 - Chapter
C2 - 21910080
SN - 9781461406495
T3 - Advances in Experimental Medicine and Biology
SP - 19
EP - 39
BT - Sphingolipids and Metabolic Disease
A2 - Cowart, Ashley
ER -