Stem cell plasticity and regenerative potential regulation through Ca2+-mediated mitochondrial nuclear crosstalk

Swati Paliwal; Heather L. Fiumera; Sujata Mohanty

doi:10.1016/j.mito.2020.10.002

Stem cell plasticity and regenerative potential regulation through Ca²⁺-mediated mitochondrial nuclear crosstalk

Swati Paliwal
, Heather L. Fiumera
, Sujata Mohanty

Biology

Binghamton University

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The multi-lineage differentiation potential is one of the prominent mechanisms through which stem cells can repair damaged tissues. The regenerative potential of stem cells is the manifestation of several changes at the structural and molecular levels in stem cells that are regulated through intricate mitochondrial-nuclear interactions maintained by Ca²⁺ ion signaling. Despite the exhilarating evidences strengthening the versatile and indispensible role of Ca²⁺ in regulating mitochondrial-nuclear interactions, the extensive details of signaling mechanisms remains largely unexplored. In this review we have discussed the effect of Ca²⁺ ion mediated mitochondrial-nuclear interactions participating in stem plasticity and its regenerative potential.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Mitochondrion
Volume	56
DOIs	https://doi.org/10.1016/j.mito.2020.10.002
State	Published - Jan 2021

Keywords

Ca signaling
Mitochondrial-nuclear interactions
Regenerative potential
Stem cell plasticity

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10.1016/j.mito.2020.10.002

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title = "Stem cell plasticity and regenerative potential regulation through Ca2+-mediated mitochondrial nuclear crosstalk",

abstract = "The multi-lineage differentiation potential is one of the prominent mechanisms through which stem cells can repair damaged tissues. The regenerative potential of stem cells is the manifestation of several changes at the structural and molecular levels in stem cells that are regulated through intricate mitochondrial-nuclear interactions maintained by Ca2+ ion signaling. Despite the exhilarating evidences strengthening the versatile and indispensible role of Ca2+ in regulating mitochondrial-nuclear interactions, the extensive details of signaling mechanisms remains largely unexplored. In this review we have discussed the effect of Ca2+ ion mediated mitochondrial-nuclear interactions participating in stem plasticity and its regenerative potential.",

keywords = "Ca signaling, Mitochondrial-nuclear interactions, Regenerative potential, Stem cell plasticity",

author = "Swati Paliwal and Fiumera, \{Heather L.\} and Sujata Mohanty",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. and Mitochondria Research Society",

year = "2021",

month = jan,

doi = "10.1016/j.mito.2020.10.002",

language = "English",

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T1 - Stem cell plasticity and regenerative potential regulation through Ca2+-mediated mitochondrial nuclear crosstalk

AU - Paliwal, Swati

AU - Fiumera, Heather L.

AU - Mohanty, Sujata

PY - 2021/1

Y1 - 2021/1

N2 - The multi-lineage differentiation potential is one of the prominent mechanisms through which stem cells can repair damaged tissues. The regenerative potential of stem cells is the manifestation of several changes at the structural and molecular levels in stem cells that are regulated through intricate mitochondrial-nuclear interactions maintained by Ca2+ ion signaling. Despite the exhilarating evidences strengthening the versatile and indispensible role of Ca2+ in regulating mitochondrial-nuclear interactions, the extensive details of signaling mechanisms remains largely unexplored. In this review we have discussed the effect of Ca2+ ion mediated mitochondrial-nuclear interactions participating in stem plasticity and its regenerative potential.

AB - The multi-lineage differentiation potential is one of the prominent mechanisms through which stem cells can repair damaged tissues. The regenerative potential of stem cells is the manifestation of several changes at the structural and molecular levels in stem cells that are regulated through intricate mitochondrial-nuclear interactions maintained by Ca2+ ion signaling. Despite the exhilarating evidences strengthening the versatile and indispensible role of Ca2+ in regulating mitochondrial-nuclear interactions, the extensive details of signaling mechanisms remains largely unexplored. In this review we have discussed the effect of Ca2+ ion mediated mitochondrial-nuclear interactions participating in stem plasticity and its regenerative potential.

KW - Ca signaling

KW - Mitochondrial-nuclear interactions

KW - Regenerative potential

KW - Stem cell plasticity

UR - https://www.scopus.com/pages/publications/85095952965

U2 - 10.1016/j.mito.2020.10.002

DO - 10.1016/j.mito.2020.10.002

M3 - Review article

C2 - 33059088

SN - 1567-7249

VL - 56

SP - 1

EP - 14

JO - Mitochondrion

JF - Mitochondrion

ER -

Stem cell plasticity and regenerative potential regulation through Ca²⁺-mediated mitochondrial nuclear crosstalk

Abstract

Keywords

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