Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis

Dongyan Tan; Neil B. Blok; Tom A. Rapoport; Thomas Walz

doi:10.1111/febs.13569

Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis

Dongyan Tan
, Neil B. Blok
, Tom A. Rapoport
, Thomas Walz

Pharmacological Sciences

Stony Brook University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.

Original language	English
Pages (from-to)	986-992
Number of pages	7
Journal	FEBS Journal
Volume	283
Issue number	6
DOIs	https://doi.org/10.1111/febs.13569
State	Published - Mar 1 2016

Keywords

AAA ATPases
Pex1-Pex6 complex
cryo-electron microscopy
peroxisome biogenesis
single-particle analysis

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10.1111/febs.13569

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title = "Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis",

abstract = "The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.",

keywords = "AAA ATPases, Pex1-Pex6 complex, cryo-electron microscopy, peroxisome biogenesis, single-particle analysis",

author = "Dongyan Tan and Blok, \{Neil B.\} and Rapoport, \{Tom A.\} and Thomas Walz",

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AU - Tan, Dongyan

AU - Blok, Neil B.

AU - Rapoport, Tom A.

AU - Walz, Thomas

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.

AB - The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.

KW - AAA ATPases

KW - Pex1-Pex6 complex

KW - cryo-electron microscopy

KW - peroxisome biogenesis

KW - single-particle analysis

UR - https://www.scopus.com/pages/publications/84961858378

U2 - 10.1111/febs.13569

DO - 10.1111/febs.13569

M3 - Article

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SN - 1742-464X

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JO - FEBS Journal

JF - FEBS Journal

IS - 6

ER -

Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis

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Keywords

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