Subcutaneous-Insulin-Resistance Syndrome

To the Editor: It is probable that every aging investigator has had the same experience, but it is frustrating to find that a current article in the Journal (July 17 issue)¹ fails to mention important original work on the same topic. Twenty-seven years ago, Moore, Mitchell, and I² studied the absorption of subcutaneously and intramuscularly injected ¹³¹I-labeled insulin, by direct measurement over the injection site. At the time, apparently no one else had studied this topic in such a direct way. Although the paper was written before we began to appreciate the implications of the Type II (beta) error, we.