Superkiller complex problems expose a cancer-cell vulnerability

Christopher U.T. Hellen; Tatyana V. Pestova

doi:10.1038/d41586-025-00086-3

Superkiller complex problems expose a cancer-cell vulnerability

Cell / Cellular Biology and Anatomical Sciences

SUNY Downstate Health Sciences University

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

When a cancer cell no longer makes a particular functioning protein, it can become dependent on another protein for survival. The identification of one such relationship has uncovered a therapeutic target.

Original language	English
Pages (from-to)	897-899
Number of pages	3
Journal	Nature
Volume	638
Issue number	8052
DOIs	https://doi.org/10.1038/d41586-025-00086-3
State	Published - Feb 27 2025

Keywords

Cancer
Medical research

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10.1038/d41586-025-00086-3

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title = "Superkiller complex problems expose a cancer-cell vulnerability",

abstract = "When a cancer cell no longer makes a particular functioning protein, it can become dependent on another protein for survival. The identification of one such relationship has uncovered a therapeutic target.",

keywords = "Cancer, Medical research",

author = "Hellen, \{Christopher U.T.\} and Pestova, \{Tatyana V.\}",

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year = "2025",

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T1 - Superkiller complex problems expose a cancer-cell vulnerability

AU - Hellen, Christopher U.T.

AU - Pestova, Tatyana V.

N1 - Publisher Copyright: © Springer Nature Limited 2025.

PY - 2025/2/27

Y1 - 2025/2/27

N2 - When a cancer cell no longer makes a particular functioning protein, it can become dependent on another protein for survival. The identification of one such relationship has uncovered a therapeutic target.

AB - When a cancer cell no longer makes a particular functioning protein, it can become dependent on another protein for survival. The identification of one such relationship has uncovered a therapeutic target.

KW - Cancer

KW - Medical research

UR - https://www.scopus.com/pages/publications/85218822958

U2 - 10.1038/d41586-025-00086-3

DO - 10.1038/d41586-025-00086-3

M3 - Comment/debate

C2 - 39910364

SN - 0028-0836

VL - 638

SP - 897

EP - 899

JO - Nature

JF - Nature

IS - 8052

ER -

Superkiller complex problems expose a cancer-cell vulnerability

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