Synaptic depression

Matthew A. Xu-Friedman

doi:10.1016/B978-0-12-809324-5.02789-9

Synaptic depression

Matthew A. Xu-Friedman

Biological Sciences

University at Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Activity at synapses can lead to changes in the amplitudes of synaptic currents and potentials. This article focusses on short-term decreases in amplitude, which are generally termed “depression.” Depression appears to arise from at least three major processes: presynaptic vesicle depletion, postsynaptic receptor desensitization, and postsynaptic receptor saturation. Additional processes have been implicated in certain situations. It is not yet clear how depression affects the processing of information in the nervous system, though some potential computational effects have been described.

Original language	English
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	725-730
Number of pages	6
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.02789-9
State	Published - Jan 1 2016

Keywords

Depletion
Depression
Desensitization
Plasticity
Saturation
Synapse
Vesicle

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10.1016/B978-0-12-809324-5.02789-9

Cite this

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AB - Activity at synapses can lead to changes in the amplitudes of synaptic currents and potentials. This article focusses on short-term decreases in amplitude, which are generally termed “depression.” Depression appears to arise from at least three major processes: presynaptic vesicle depletion, postsynaptic receptor desensitization, and postsynaptic receptor saturation. Additional processes have been implicated in certain situations. It is not yet clear how depression affects the processing of information in the nervous system, though some potential computational effects have been described.

KW - Depletion

KW - Depression

KW - Desensitization

KW - Plasticity

KW - Saturation

KW - Synapse

KW - Vesicle

UR - https://www.scopus.com/pages/publications/85079565851

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DO - 10.1016/B978-0-12-809324-5.02789-9

M3 - Chapter

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EP - 730

BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

PB - Elsevier Science Ltd.

ER -

Synaptic depression

Abstract

Keywords

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