Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

Nguyen Hai Nam; Young Jae You; Yong Kim; Dong Ho Hong; Hwan Mook Kim; Byung Zun Ahn

doi:10.1016/S0960-894X(01)00165-2

Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

Nguyen Hai Nam
, Young Jae You
, Yong Kim
, Dong Ho Hong
, Hwan Mook Kim
, Byung Zun Ahn

Pharmaceutical Sciences

University at Buffalo

Chungnam National University
Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.

Original language	English
Pages (from-to)	1173-1176
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(01)00165-2
State	Published - May 7 2001

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title = "Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity",

abstract = "A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.",

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doi = "10.1016/S0960-894X(01)00165-2",

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T1 - Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

AU - Nam, Nguyen Hai

AU - You, Young Jae

AU - Kim, Yong

AU - Hong, Dong Ho

AU - Kim, Hwan Mook

AU - Ahn, Byung Zun

PY - 2001/5/7

Y1 - 2001/5/7

N2 - A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.

AB - A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.

UR - https://www.scopus.com/pages/publications/0035821377

U2 - 10.1016/S0960-894X(01)00165-2

DO - 10.1016/S0960-894X(01)00165-2

M3 - Article

C2 - 11354370

SN - 0960-894X

VL - 11

SP - 1173

EP - 1176

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

Abstract

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