Synthesis and biological evaluation of C-3′NH/C-10 and C-2/C-10 modified paclitaxel analogues

Erkan Baloglu; Jeannine M. Hoch; Sabarni K. Chatterjee; Rudravajhala Ravindra; Susan Bane; David G.I. Kingston

doi:10.1016/S0968-0896(02)00608-9

Synthesis and biological evaluation of C-3′NH/C-10 and C-2/C-10 modified paclitaxel analogues

Erkan Baloglu
, Jeannine M. Hoch
, Sabarni K. Chatterjee
, Rudravajhala Ravindra
, Susan Bane
, David G.I. Kingston

Chemistry

Binghamton University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Concurrent modifications on the C-3′NH/C-10, and C-2/C-10 positions on paclitaxel were carried out as a way of investigating possible synergistic effects. The biological activities of these analogues were evaluated in both a microtubule assembly assay and human ovarian cancer (A2780) and prostate cancer (PC3) cytotoxicity assay. In some cases the doubly modified analogues were more active than would have been predicted based on the activity of the singly modified analogues, indicating probable synergistic effects.

Original language	English
Pages (from-to)	1557-1568
Number of pages	12
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	7
DOIs	https://doi.org/10.1016/S0968-0896(02)00608-9
State	Published - Apr 2003

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abstract = "Concurrent modifications on the C-3′NH/C-10, and C-2/C-10 positions on paclitaxel were carried out as a way of investigating possible synergistic effects. The biological activities of these analogues were evaluated in both a microtubule assembly assay and human ovarian cancer (A2780) and prostate cancer (PC3) cytotoxicity assay. In some cases the doubly modified analogues were more active than would have been predicted based on the activity of the singly modified analogues, indicating probable synergistic effects.",

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AU - Baloglu, Erkan

AU - Hoch, Jeannine M.

AU - Chatterjee, Sabarni K.

AU - Ravindra, Rudravajhala

AU - Bane, Susan

AU - Kingston, David G.I.

PY - 2003/4

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AB - Concurrent modifications on the C-3′NH/C-10, and C-2/C-10 positions on paclitaxel were carried out as a way of investigating possible synergistic effects. The biological activities of these analogues were evaluated in both a microtubule assembly assay and human ovarian cancer (A2780) and prostate cancer (PC3) cytotoxicity assay. In some cases the doubly modified analogues were more active than would have been predicted based on the activity of the singly modified analogues, indicating probable synergistic effects.

UR - https://www.scopus.com/pages/publications/0037375622

U2 - 10.1016/S0968-0896(02)00608-9

DO - 10.1016/S0968-0896(02)00608-9

M3 - Article

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JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

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ER -

Synthesis and biological evaluation of C-3′NH/C-10 and C-2/C-10 modified paclitaxel analogues

Abstract

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