Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Susan Clardy-James; Oleg G. Chepurny; Colin A. Leech; George G. Holz; Robert P. Doyle

doi:10.1002/cmdc.201200461

Synthesis, Characterization and Pharmacodynamics of Vitamin-B₁₂-Conjugated Glucagon-Like Peptide-1

Susan Clardy-James
, Oleg G. Chepurny
, Colin A. Leech
, George G. Holz
, Robert P. Doyle

Medicine

Upstate Medical University

Syracuse University
SUNY Upstate Medical University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of typeII diabetes. A new vitaminB₁₂-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitaminB₁₂ oral uptake pathway for peptide delivery.

Original language	English
Pages (from-to)	582-586
Number of pages	5
Journal	ChemMedChem
Volume	8
Issue number	4
DOIs	https://doi.org/10.1002/cmdc.201200461
State	Published - Apr 2013

Keywords

Glucagon-like peptide-1 (GLP-1)
Human pancreatic islets
Insulinotropic effects
Receptor agonists
VitaminB

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10.1002/cmdc.201200461

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abstract = "Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of typeII diabetes. A new vitaminB12-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitaminB12 oral uptake pathway for peptide delivery.",

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AU - Doyle, Robert P.

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KW - Glucagon-like peptide-1 (GLP-1)

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KW - Insulinotropic effects

KW - Receptor agonists

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Synthesis, Characterization and Pharmacodynamics of Vitamin-B₁₂-Conjugated Glucagon-Like Peptide-1

Abstract

Keywords

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