Synthesis of Methyl 2,3‐Bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]hepta‐2,5‐diene‐6‐carboxylate Bis(N‐methylcarbamate) Derivatives as Potential Antitumor Agents

Wayne K. Anderson; Bipi Mulumba

doi:10.1002/jps.2600730844

Synthesis of Methyl 2,3‐Bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]hepta‐2,5‐diene‐6‐carboxylate Bis(N‐methylcarbamate) Derivatives as Potential Antitumor Agents

Wayne K. Anderson
, Bipi Mulumba

Pharmaceutical Sciences

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Methyl 2,3‐bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]‐hepta‐2,5‐diene‐6‐carboxylate bis(N‐methylcarbamate) along with the p‐chlorophenyl and p‐nitrophenyl analogues were synthesized using a Diels Alder reaction. The title compound and the p‐chlorophenyl analogue were inactive against murine P388 lymphocytic leukemia.

Original language	English
Pages (from-to)	1182-1183
Number of pages	2
Journal	Journal of Pharmaceutical Sciences
Volume	73
Issue number	8
DOIs	https://doi.org/10.1002/jps.2600730844
State	Published - Aug 1984

Keywords

7‐Oxabicyclo[2.2.1]hepta‐2,5‐diene derivatives—synthesis, antitumor activity
Bis‐carbamates—synthesis, antitumor activity

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10.1002/jps.2600730844

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@article{9f0a3223b1f44f63a1f6ed8033322695,

title = "Synthesis of Methyl 2,3‐Bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]hepta‐2,5‐diene‐6‐carboxylate Bis(N‐methylcarbamate) Derivatives as Potential Antitumor Agents",

abstract = "Methyl 2,3‐bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]‐hepta‐2,5‐diene‐6‐carboxylate bis(N‐methylcarbamate) along with the p‐chlorophenyl and p‐nitrophenyl analogues were synthesized using a Diels Alder reaction. The title compound and the p‐chlorophenyl analogue were inactive against murine P388 lymphocytic leukemia.",

keywords = "7‐Oxabicyclo[2.2.1]hepta‐2,5‐diene derivatives—synthesis, antitumor activity, Bis‐carbamates—synthesis, antitumor activity",

author = "Anderson, \{Wayne K.\} and Bipi Mulumba",

year = "1984",

month = aug,

doi = "10.1002/jps.2600730844",

language = "English",

volume = "73",

pages = "1182--1183",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "Elsevier B.V.",

number = "8",

}

Synthesis of Methyl 2,3‐Bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]hepta‐2,5‐diene‐6‐carboxylate Bis(N‐methylcarbamate) Derivatives as Potential Antitumor Agents. / Anderson, Wayne K.; Mulumba, Bipi.
In: Journal of Pharmaceutical Sciences, Vol. 73, No. 8, 08.1984, p. 1182-1183.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of Methyl 2,3‐Bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]hepta‐2,5‐diene‐6‐carboxylate Bis(N‐methylcarbamate) Derivatives as Potential Antitumor Agents

AU - Anderson, Wayne K.

AU - Mulumba, Bipi

PY - 1984/8

Y1 - 1984/8

N2 - Methyl 2,3‐bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]‐hepta‐2,5‐diene‐6‐carboxylate bis(N‐methylcarbamate) along with the p‐chlorophenyl and p‐nitrophenyl analogues were synthesized using a Diels Alder reaction. The title compound and the p‐chlorophenyl analogue were inactive against murine P388 lymphocytic leukemia.

AB - Methyl 2,3‐bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]‐hepta‐2,5‐diene‐6‐carboxylate bis(N‐methylcarbamate) along with the p‐chlorophenyl and p‐nitrophenyl analogues were synthesized using a Diels Alder reaction. The title compound and the p‐chlorophenyl analogue were inactive against murine P388 lymphocytic leukemia.

KW - 7‐Oxabicyclo[2.2.1]hepta‐2,5‐diene derivatives—synthesis, antitumor activity

KW - Bis‐carbamates—synthesis, antitumor activity

UR - https://www.scopus.com/pages/publications/0021145035

U2 - 10.1002/jps.2600730844

DO - 10.1002/jps.2600730844

M3 - Article

C2 - 6491932

SN - 0022-3549

VL - 73

SP - 1182

EP - 1183

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 8

ER -

Synthesis of Methyl 2,3‐Bis(hydroxymethyl)‐5‐phenyl‐7‐oxabicyclo[2.2.1]hepta‐2,5‐diene‐6‐carboxylate Bis(N‐methylcarbamate) Derivatives as Potential Antitumor Agents

Abstract

Keywords

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