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Synthesis of orthogonally protected L-homocysteine and L-2-amino-4-phophonobutanoic acid from L-homoserine

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Abstract

Convenient syntheses of N-tert-butoxycarbonyl-S-p-methoxybenzyl-L-homocysteine benzyl ester and benzyl L-4-dimethylphosphono-2-N-phthalimidobutanoate from commercially available L-homoserine are described along with their incorporation into dipeptides.

Original languageEnglish
Pages (from-to)810-814
Number of pages5
JournalSynthesis (Germany)
Issue number7
DOIs
StatePublished - 1995

Keywords

  • L-2-amino-4- bromobutyrate
  • L-2-amino-4-phosphonobutyrate
  • L-homocysteine
  • L-homoserine

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