Abstract
Emerging preclinical autism research has shown the therapeutic promise of pharmacological inhibitors for epigenetic enzymes, such as histone deacetylases (HDAC), euchromatic histone methyltransferases (EHMT), and lysine-specific histone demethylase 1A (LSD1). These interventions restore gene expression, synaptic function, and behavioral performance in autism models, highlighting a new strategy for autism treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 764-767 |
| Number of pages | 4 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 45 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2024 |
Keywords
- autism
- epigenetics
- histone modification
- social deficits
- synaptic
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