Targeting the dynamic HSP90 complex in cancer

Jane Trepel; Mehdi Mollapour; Giuseppe Giaccone; Len Neckers

doi:10.1038/nrc2887

Targeting the dynamic HSP90 complex in cancer

Jane Trepel
, Mehdi Mollapour
, Giuseppe Giaccone
, Len Neckers

Urology

Upstate Medical University

National Institutes of Health

Research output: Contribution to journal › Review article › peer-review

1357 Scopus citations

Abstract

The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to facilitate the function of numerous oncoproteins, and it can be argued that cancer cells are 'addicted' to HSP90. However, although recent reports of the early clinical efficacy of HSP90 inhibitors are encouraging, the optimal use of HSP90-targeted therapeutics will depend on understanding the complexity of HSP90 regulation and the degree to which HSP90 participates in both neoplastic and normal cellular physiology.

Original language	English
Pages (from-to)	537-549
Number of pages	13
Journal	Nature Reviews Cancer
Volume	10
Issue number	8
DOIs	https://doi.org/10.1038/nrc2887
State	Published - Aug 2010

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10.1038/nrc2887

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Targeting the dynamic HSP90 complex in cancer

Abstract

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