Abstract
This chapter reviews volumetric studies of age-related differences in the human brain observed in vivo using magnetic resonance imaging (MRI), and presents several examples of their impact on cognitive performance in healthy adults. Age-related differences in brain anatomy are regional and differential. The preponderance of the evidence indicated that prefrontal cortex is the region of the greatest age-related vulnerability. However, to date, almost all studies were conducted in a cross-sectional design, and a few longitudinal studies were limited in their duration and scope of the examined brain locations.
| Original language | English |
|---|---|
| Title of host publication | New Frontiers in Cognitive Aging |
| Publisher | Oxford University Press |
| ISBN (Electronic) | 9780191689369 |
| ISBN (Print) | 9780198525691 |
| DOIs | |
| State | Published - Mar 22 2012 |
Keywords
- Age-related change
- Aging
- Brain imaging
- Cognition
- Cognitive performance
- Prefrontal cortex
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