Abstract
A series of N‐substituted α‐5,9‐dimethyl‐6,7‐benzomorphans bearing N‐2‐hydroxyalkyl and N‐2‐bromoalkyl substituents have been synthesized and their analgesic, hypothermic, and depressant activities determined. The analgesic activities were not outstanding but the N‐2‐bromoethyl‐ and the N‐2‐bromopropyl derivatives produced prolonged hypothermia and depression. Possible mechanisms of these prolonged actions are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 884-887 |
| Number of pages | 4 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 57 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1968 |
Keywords
- Analgesic activity
- Depressant activity
- Hypothermic activity
- Pharmacological screening—5,9–dimethyl–6,7–benzomorphans
- α‐5,9‐dimethyl–6,7–benzomorphans, N–substituted—synthesis
Fingerprint
Dive into the research topics of 'The analgesic, hypothermic, and depressant activities of some N‐substituted α‐5,9‐dimethyl‐6,7‐benzomorphans'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver