The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes

Yvonne Gar Yun Chan; Hwan Keun Kim; Olaf Schneewind; Dominique Missiakas

doi:10.1074/jbc.M114.567669

The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes

Yvonne Gar Yun Chan
, Hwan Keun Kim
, Olaf Schneewind
, Dominique Missiakas

Microbiology and Immunology

Stony Brook University

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Background: Staphylococcus aureus LcpABC attach wall teichoic acids (WTA) to peptidoglycan. Results: S. aureus capsular polysaccharide (CP5) is linked to peptidoglycan in a manner requiring lcpABC genes. Conclusion: Unlike WTA, CP5 attachment is mediated preferentially by LcpC. Significance: LCP proteins display substrate preferences for the transfer of undecaprenyl-bound polymers to peptidoglycan.

Original language	English
Pages (from-to)	15680-15690
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M114.567669
State	Published - May 30 2014

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abstract = "Background: Staphylococcus aureus LcpABC attach wall teichoic acids (WTA) to peptidoglycan. Results: S. aureus capsular polysaccharide (CP5) is linked to peptidoglycan in a manner requiring lcpABC genes. Conclusion: Unlike WTA, CP5 attachment is mediated preferentially by LcpC. Significance: LCP proteins display substrate preferences for the transfer of undecaprenyl-bound polymers to peptidoglycan.",

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AU - Kim, Hwan Keun

AU - Schneewind, Olaf

AU - Missiakas, Dominique

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: Staphylococcus aureus LcpABC attach wall teichoic acids (WTA) to peptidoglycan. Results: S. aureus capsular polysaccharide (CP5) is linked to peptidoglycan in a manner requiring lcpABC genes. Conclusion: Unlike WTA, CP5 attachment is mediated preferentially by LcpC. Significance: LCP proteins display substrate preferences for the transfer of undecaprenyl-bound polymers to peptidoglycan.

AB - Background: Staphylococcus aureus LcpABC attach wall teichoic acids (WTA) to peptidoglycan. Results: S. aureus capsular polysaccharide (CP5) is linked to peptidoglycan in a manner requiring lcpABC genes. Conclusion: Unlike WTA, CP5 attachment is mediated preferentially by LcpC. Significance: LCP proteins display substrate preferences for the transfer of undecaprenyl-bound polymers to peptidoglycan.

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DO - 10.1074/jbc.M114.567669

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The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes

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