The distribution of intra-twin birth weight discordance and its association with total twin birth weight, gestational age, and neonatal mortality

Objective: To determine an appropriate cutoff value to differentiate physiologic and pathologic birth weight discordance, to determine the prevalence of birth weight discordance ≥25% among twin pregnancies in different sub-populations, and to examine its clinical significance. Study design: Historical cohort study of 147,262 twin sets registered in the United States between 1995 and 1997. Results: The prevalence of birth weight discordance ≥25% among twin pregnancies was 8.6%. The prevalence of birth weight discordance ≥25% was significantly decreased with increasing total twin birth weight deciles, was more frequently found in twins with discordant gender (9.1%) than in those twins with concordant gender (8.3%) and in mothers whose age was 30 years or older (9.1%) than those of younger mothers (8.1%). Birth weight discordance ≥25% was associated with earlier gestational age at delivery (35.0 weeks versus 36.0 weeks) and higher neonatal mortality (5.4% versus 2.3%) as compared to twins with lower birth weight discordance. Conclusions: The prevalence of birth weight discordance ≥25% among twin pregnancies was 8.6%, which is associated with lower gestational age at delivery and higher neonatal mortality rates, and may represent a pathologic process.