The effect of diflunisal administration on platelet aggregation and cerebral blood flow

D. P. Mikhailidis; M. A. Barradas; I. Temple-Savage; P. J. Streete; J. A. Henry; I. M. James; P. Dandona

The effect of diflunisal administration on platelet aggregation and cerebral blood flow

D. P. Mikhailidis
, M. A. Barradas
, I. Temple-Savage
, P. J. Streete
, J. A. Henry
, I. M. James
, P. Dandona

Medicine

University at Buffalo

Metabolic Unit

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The effect of a high dose of diflunisal (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in 8 healthy volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was reversed within 24 hours after the last dose of diflunisal. There was, however, no correlation between the anti-aggregatory effect of diflunisal and its plasma concentration. Diflunisal did not alter cerebral blood flow.

Original language	English
Pages (from-to)	255-259
Number of pages	5
Journal	Pharmatherapeutica
Volume	4
Issue number	4
State	Published - 1985

Cite this

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title = "The effect of diflunisal administration on platelet aggregation and cerebral blood flow",

abstract = "The effect of a high dose of diflunisal (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in 8 healthy volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was reversed within 24 hours after the last dose of diflunisal. There was, however, no correlation between the anti-aggregatory effect of diflunisal and its plasma concentration. Diflunisal did not alter cerebral blood flow.",

author = "Mikhailidis, \{D. P.\} and Barradas, \{M. A.\} and I. Temple-Savage and Streete, \{P. J.\} and Henry, \{J. A.\} and James, \{I. M.\} and P. Dandona",

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T1 - The effect of diflunisal administration on platelet aggregation and cerebral blood flow

AU - Mikhailidis, D. P.

AU - Barradas, M. A.

AU - Temple-Savage, I.

AU - Streete, P. J.

AU - Henry, J. A.

AU - James, I. M.

AU - Dandona, P.

PY - 1985

Y1 - 1985

N2 - The effect of a high dose of diflunisal (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in 8 healthy volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was reversed within 24 hours after the last dose of diflunisal. There was, however, no correlation between the anti-aggregatory effect of diflunisal and its plasma concentration. Diflunisal did not alter cerebral blood flow.

AB - The effect of a high dose of diflunisal (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in 8 healthy volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was reversed within 24 hours after the last dose of diflunisal. There was, however, no correlation between the anti-aggregatory effect of diflunisal and its plasma concentration. Diflunisal did not alter cerebral blood flow.

UR - https://www.scopus.com/pages/publications/0021844990

M3 - Article

C2 - 4059301

SN - 0308-051X

VL - 4

SP - 255

EP - 259

JO - Pharmatherapeutica

JF - Pharmatherapeutica

IS - 4

ER -

The effect of diflunisal administration on platelet aggregation and cerebral blood flow

Abstract

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