TY - GEN
T1 - The effects of the fiber alignment on the behavior of rat osteosarcoma and mouse osteoblast cells
AU - Liu, Ying
AU - Ghosh, Kaustabh
AU - Sokolov, Jon
AU - Rafailovich, Miriam
PY - 2007
Y1 - 2007
N2 - Electrospinning is a promising method to construct biomaterial scaffolds for tissue engineering applications, but the efficacy depends on how the substrate topography affects cell function.1 In order to test whether the response of normal and cancerous cells differs, we tested the response of mouse osteoblasts (MC3T3-E1) and rat osteosarcoma (ROS). Poly (methyl methacrylate) fibers were electrospun into rectangular meshes with fiber diameters of 8.64μ on a rigid support. Examination of cell morphology revealed that both types of cells can adhere to the scaffolds. In both cases the cells on the fibers were far more oriented than those on the planar surface. The aspect ration of the MC3T3 cells though was significantly larger than that of the ROS cells, indicating that cancer cells may not be able to adapt to the underlying morphology as easily as normal cells.
AB - Electrospinning is a promising method to construct biomaterial scaffolds for tissue engineering applications, but the efficacy depends on how the substrate topography affects cell function.1 In order to test whether the response of normal and cancerous cells differs, we tested the response of mouse osteoblasts (MC3T3-E1) and rat osteosarcoma (ROS). Poly (methyl methacrylate) fibers were electrospun into rectangular meshes with fiber diameters of 8.64μ on a rigid support. Examination of cell morphology revealed that both types of cells can adhere to the scaffolds. In both cases the cells on the fibers were far more oriented than those on the planar surface. The aspect ration of the MC3T3 cells though was significantly larger than that of the ROS cells, indicating that cancer cells may not be able to adapt to the underlying morphology as easily as normal cells.
UR - https://www.scopus.com/pages/publications/48749105890
U2 - 10.1109/NEBC.2007.4413354
DO - 10.1109/NEBC.2007.4413354
M3 - Conference contribution
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 213
EP - 214
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -