The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction

Chaofeng Dai; Lifang Wang; Jia Sheng; Hanjing Peng; Alexander Boryanov Draganov; Zhen Huang; Binghe Wang

doi:10.1039/c0cc04546b

The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction

Chaofeng Dai
, Lifang Wang
, Jia Sheng
, Hanjing Peng
, Alexander Boryanov Draganov
, Zhen Huang
, Binghe Wang

Chemistry

University at Albany

Georgia State University

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.

Original language	English
Pages (from-to)	3598-3600
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	12
DOIs	https://doi.org/10.1039/c0cc04546b
State	Published - Mar 8 2011

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title = "The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction",

abstract = "The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.",

author = "Chaofeng Dai and Lifang Wang and Jia Sheng and Hanjing Peng and Draganov, \{Alexander Boryanov\} and Zhen Huang and Binghe Wang",

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AU - Dai, Chaofeng

AU - Wang, Lifang

AU - Sheng, Jia

AU - Peng, Hanjing

AU - Draganov, Alexander Boryanov

AU - Huang, Zhen

AU - Wang, Binghe

PY - 2011/3/8

Y1 - 2011/3/8

N2 - The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.

AB - The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.

UR - https://www.scopus.com/pages/publications/79952396963

U2 - 10.1039/c0cc04546b

DO - 10.1039/c0cc04546b

M3 - Article

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VL - 47

SP - 3598

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JO - Chemical Communications

JF - Chemical Communications

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The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction

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