The immunological identity of tumor: Self implications

Jason Miska; Priyadharshini Devarajan; Zhibin Chen

doi:10.4161/onco.23794

The immunological identity of tumor: Self implications

Jason Miska
, Priyadharshini Devarajan
, Zhibin Chen

Microbiology and Immunology

Stony Brook University

University of Miami

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

Original language	English
Article number	e23794
Journal	OncoImmunology
Volume	2
Issue number	4
DOIs	https://doi.org/10.4161/onco.23794
State	Published - Apr 2013

Keywords

Altered self
Autoimmunity
Cancer
Immunoprivileged self
Regulatory T cell (Treg)

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10.4161/onco.23794

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AB - By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

KW - Altered self

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KW - Cancer

KW - Immunoprivileged self

KW - Regulatory T cell (Treg)

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The immunological identity of tumor: Self implications

Abstract

Keywords

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