The mobile genetic element rd2 affects colonization potential of different GAS serotypes

Laura C. Cook

doi:10.1128/IAI.00185-21

The mobile genetic element rd2 affects colonization potential of different GAS serotypes

Laura C. Cook

Biology

Binghamton University

Research output: Contribution to journal › Review article › peer-review

Abstract

M-type 28 (M28) Streptococcus pyogenes (group A Streptococcus [GAS]) strains are highly associated with life-threatening puerperal infections. Genome sequencing has revealed a large mobile genetic element, RD2, present in most M28 GAS isolates but not found widely in other serotypes. Previous studies have linked RD2 to the ability of M28 GAS to colonize the vaginal tract. A new study by Roshika and colleagues (R. Roshika, I. Jain, J. Medicielo, J. Wächter, J. L. Danger, P. Sumby, Infect Immun 89:e00722-20, 2021, https://doi.org/10.1128/IAI.00722-20) used gain-of-function mutants in three different GAS serotypes to help determine why RD2 appears to have a serotype preference and what that could mean for GAS mucosal colonization and pathogenesis.

Original language	English
Article number	e00185-21
Journal	Infection and Immunity
Volume	89
Issue number	8
DOIs	https://doi.org/10.1128/IAI.00185-21
State	Published - Jul 1 2021

Keywords

Puerperal sepsis
RD2
Streptococcus pyogenes

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10.1128/IAI.00185-21

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title = "The mobile genetic element rd2 affects colonization potential of different GAS serotypes",

abstract = "M-type 28 (M28) Streptococcus pyogenes (group A Streptococcus [GAS]) strains are highly associated with life-threatening puerperal infections. Genome sequencing has revealed a large mobile genetic element, RD2, present in most M28 GAS isolates but not found widely in other serotypes. Previous studies have linked RD2 to the ability of M28 GAS to colonize the vaginal tract. A new study by Roshika and colleagues (R. Roshika, I. Jain, J. Medicielo, J. W{\"a}chter, J. L. Danger, P. Sumby, Infect Immun 89:e00722-20, 2021, https://doi.org/10.1128/IAI.00722-20) used gain-of-function mutants in three different GAS serotypes to help determine why RD2 appears to have a serotype preference and what that could mean for GAS mucosal colonization and pathogenesis.",

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T1 - The mobile genetic element rd2 affects colonization potential of different GAS serotypes

AU - Cook, Laura C.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - M-type 28 (M28) Streptococcus pyogenes (group A Streptococcus [GAS]) strains are highly associated with life-threatening puerperal infections. Genome sequencing has revealed a large mobile genetic element, RD2, present in most M28 GAS isolates but not found widely in other serotypes. Previous studies have linked RD2 to the ability of M28 GAS to colonize the vaginal tract. A new study by Roshika and colleagues (R. Roshika, I. Jain, J. Medicielo, J. Wächter, J. L. Danger, P. Sumby, Infect Immun 89:e00722-20, 2021, https://doi.org/10.1128/IAI.00722-20) used gain-of-function mutants in three different GAS serotypes to help determine why RD2 appears to have a serotype preference and what that could mean for GAS mucosal colonization and pathogenesis.

AB - M-type 28 (M28) Streptococcus pyogenes (group A Streptococcus [GAS]) strains are highly associated with life-threatening puerperal infections. Genome sequencing has revealed a large mobile genetic element, RD2, present in most M28 GAS isolates but not found widely in other serotypes. Previous studies have linked RD2 to the ability of M28 GAS to colonize the vaginal tract. A new study by Roshika and colleagues (R. Roshika, I. Jain, J. Medicielo, J. Wächter, J. L. Danger, P. Sumby, Infect Immun 89:e00722-20, 2021, https://doi.org/10.1128/IAI.00722-20) used gain-of-function mutants in three different GAS serotypes to help determine why RD2 appears to have a serotype preference and what that could mean for GAS mucosal colonization and pathogenesis.

KW - Puerperal sepsis

KW - RD2

KW - Streptococcus pyogenes

UR - https://www.scopus.com/pages/publications/85111644417

U2 - 10.1128/IAI.00185-21

DO - 10.1128/IAI.00185-21

M3 - Review article

C2 - 33972369

SN - 0019-9567

VL - 89

JO - Infection and Immunity

JF - Infection and Immunity

IS - 8

M1 - e00185-21

ER -

The mobile genetic element rd2 affects colonization potential of different GAS serotypes

Abstract

Keywords

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