The pathway of bone fluid flow as defined by in vivo intramedullary pressure and streaming potential measurements

The pathway of bone fluid flow response to a step-load was identified in vivo using intramedullary pressure (ImP) and streaming potential (SP) measurements. This allowed a quantitative comparison between the mechanisms of mechanotransduction and mechanoelectrotransduction, and their role in describing bone fluid flow. ImP and SP relaxation demonstrated complex decay patterns with multiple relaxation times. The different relaxation responses of ImP and SP indicated existence of an electrokinetic effect in the strain generated potential measurement, and participation of larger pore size in bone fluid flow.