Abstract
ABSTRACT: Neuropsychiatric disorders are difficult to diagnose because of phenotypic heterogeneity within and symptomatic overlap between disorders. This review describes how genomics and blood-based gene expression have shown potential as biomarkers for neuropsychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder) yet also discusses how a complex genetic landscape has limited sole genetic diagnostic tools for these disorders. In addition to their potential use as classifiers for neuropsychiatric disorders, genomic and blood-based biomarkers have revealed clues to the molecular pathways contributing to etiology. A comprehensive overview of studies to date has been given, and the authors provide suggestions for steps to be taken to ultimately move the laboratory-based classifiers towards application in a clinical setting. Furthermore, they share their vision for the future of these classifiers, both in clinical application and in opening up new ways to gain insights into the underlying biology.
| Original language | English |
|---|---|
| Pages (from-to) | 677-695 |
| Number of pages | 19 |
| Journal | Expert Review of Molecular Diagnostics |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2 2016 |
Keywords
- Neuropsychiatric disorders
- bipolar disorder
- blood-based gene expression
- diagnostic classifiers
- genomics
- major depressive disorder
- schizophrenia
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