The role of inflammation in the pathogenesis of colorectal cancer

Beth B. McConnell; Vincent W. Yang

doi:10.1007/s11888-009-0011-z

The role of inflammation in the pathogenesis of colorectal cancer

Beth B. McConnell
, Vincent W. Yang

Medicine, Chair

Stony Brook University

Emory University

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.

Original language	English
Pages (from-to)	69-74
Number of pages	6
Journal	Current Colorectal Cancer Reports
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s11888-009-0011-z
State	Published - Apr 2009

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title = "The role of inflammation in the pathogenesis of colorectal cancer",

abstract = "Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.",

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AU - McConnell, Beth B.

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PY - 2009/4

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N2 - Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.

AB - Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.

UR - https://www.scopus.com/pages/publications/77951254355

U2 - 10.1007/s11888-009-0011-z

DO - 10.1007/s11888-009-0011-z

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EP - 74

JO - Current Colorectal Cancer Reports

JF - Current Colorectal Cancer Reports

IS - 2

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The role of inflammation in the pathogenesis of colorectal cancer

Abstract

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