The role of lipocalin-2 in age-related macular degeneration (AMD)

Sayan Ghosh; Nadezda Stepicheva; Meysam Yazdankhah; Peng Shang; Alan M. Watson; Stacey Hose; Haitao Liu; Joseph Weiss; J. Samuel Zigler; Mallika Valapala; Simon C. Watkins; Debasish Sinha

doi:10.1007/s00018-019-03423-8

The role of lipocalin-2 in age-related macular degeneration (AMD)

Sayan Ghosh
, Nadezda Stepicheva
, Meysam Yazdankhah
, Peng Shang
, Alan M. Watson
, Stacey Hose
, Haitao Liu
, Joseph Weiss
, J. Samuel Zigler
, Mallika Valapala
, Simon C. Watkins
, Debasish Sinha

Biological & Vision Sciences

College of Optometry

University of Pittsburgh
Johns Hopkins University
Indiana University Bloomington

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.

Original language	English
Pages (from-to)	835-851
Number of pages	17
Journal	Cellular and Molecular Life Sciences
Volume	77
Issue number	5
DOIs	https://doi.org/10.1007/s00018-019-03423-8
State	Published - Mar 1 2020

Keywords

AKT2 signaling
Age-related macular degeneration (AMD)
Inflammation
Lipocalin-2 (LCN-2)
Retinal degeneration

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10.1007/s00018-019-03423-8

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title = "The role of lipocalin-2 in age-related macular degeneration (AMD)",

abstract = "Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.",

keywords = "AKT2 signaling, Age-related macular degeneration (AMD), Inflammation, Lipocalin-2 (LCN-2), Retinal degeneration",

author = "Sayan Ghosh and Nadezda Stepicheva and Meysam Yazdankhah and Peng Shang and Watson, \{Alan M.\} and Stacey Hose and Haitao Liu and Joseph Weiss and Zigler, \{J. Samuel\} and Mallika Valapala and Watkins, \{Simon C.\} and Debasish Sinha",

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doi = "10.1007/s00018-019-03423-8",

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T1 - The role of lipocalin-2 in age-related macular degeneration (AMD)

AU - Ghosh, Sayan

AU - Stepicheva, Nadezda

AU - Yazdankhah, Meysam

AU - Shang, Peng

AU - Watson, Alan M.

AU - Hose, Stacey

AU - Liu, Haitao

AU - Weiss, Joseph

AU - Zigler, J. Samuel

AU - Valapala, Mallika

AU - Watkins, Simon C.

AU - Sinha, Debasish

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.

AB - Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.

KW - AKT2 signaling

KW - Age-related macular degeneration (AMD)

KW - Inflammation

KW - Lipocalin-2 (LCN-2)

KW - Retinal degeneration

UR - https://www.scopus.com/pages/publications/85077602420

U2 - 10.1007/s00018-019-03423-8

DO - 10.1007/s00018-019-03423-8

M3 - Review article

C2 - 31901947

SN - 1420-682X

VL - 77

SP - 835

EP - 851

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 5

ER -

The role of lipocalin-2 in age-related macular degeneration (AMD)

Abstract

Keywords

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