Thromboembolic events associated with neuroform stent™ in endovascular treatment of intracranial aneurysms: Clinical investigative study

Background The incidence of thromboembolic events associated with Neuroform stent™ (Boston Scientific Target, Fremont, CA) is known from previous studies but there are uncertainties of scale. Purpose To report our rate of ischemic events associated with Neuroform stent™. Methods Consecutive patients treated with Neuroform stent™ for intracranial aneurysms were prospectively enrolled from January 2003 to August 2006. Thromboembolic events as well as clinical outcomes were measured. Mean follow-up was 12 months. RESULTS Successful stent deployment was achieved in (65/67) 97% of patients without any ischemic event. However, postoperative thromboembolic events were observed in 3 patients despite being on clopidogrel and aspirin. These 3 patients demonstrated poor platelet inhibitions in platelet aggregation (aggregometry) studies, and were successfully treated with intravenous eptifibatide with good outcome. The majority of the patients had good outcomes [Glasgow Outcome Score (GOS) 5 or National Institute of Health Stroke Scale (NIHSS) 0 in (63/67) 94%, GOS 4 or NIHSS 2 in 1 patient, and GOS 3 or NIHSS 4 was observed in 3 cases]. CONCLUSION Our study reveals that the thromboembolic events associated with Neuroform stent™ may present in a delayed fashion. These events can be successfully treated with good outcome. Therefore, postoperative close follow-up is strongly recommended for all Neuroform stent™-treated patients.