Thrombolysis in patients with transient neurologic deficits

Patrick Lyden; M. Lu; T. Kwiatkowski; M. Frankel; S. Levine; J. Broderick; T. Brott

doi:10.1212/WNL.57.11.2125

Thrombolysis in patients with transient neurologic deficits

Patrick Lyden
, M. Lu
, T. Kwiatkowski
, M. Frankel
, S. Levine
, J. Broderick
, T. Brott

Neurology

SUNY Downstate Health Sciences University

University of California at San Diego
Department of Veterans Affairs
Henry Ford Health System
Northwell Health System
Emory University
University of Cincinnati
Mayo Clinic in Jacksonville, Florida

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5% of recombinant tissue-type plasminogen activator (rt-PA)-treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA-treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.

Original language	English
Pages (from-to)	2125-2128
Number of pages	4
Journal	Neurology
Volume	57
Issue number	11
DOIs	https://doi.org/10.1212/WNL.57.11.2125
State	Published - Dec 11 2001

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title = "Thrombolysis in patients with transient neurologic deficits",

abstract = "What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6\% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5\% of recombinant tissue-type plasminogen activator (rt-PA)-treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA-treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.",

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AU - Lyden, Patrick

AU - Lu, M.

AU - Kwiatkowski, T.

AU - Frankel, M.

AU - Levine, S.

AU - Broderick, J.

AU - Brott, T.

PY - 2001/12/11

Y1 - 2001/12/11

N2 - What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5% of recombinant tissue-type plasminogen activator (rt-PA)-treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA-treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.

AB - What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5% of recombinant tissue-type plasminogen activator (rt-PA)-treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA-treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.

UR - https://www.scopus.com/pages/publications/0035846638

U2 - 10.1212/WNL.57.11.2125

DO - 10.1212/WNL.57.11.2125

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SN - 0028-3878

VL - 57

SP - 2125

EP - 2128

JO - Neurology

JF - Neurology

IS - 11

ER -

Thrombolysis in patients with transient neurologic deficits

Abstract

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