Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1038/s41372-020-0594-4

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

University at Buffalo

University of Iowa
Children's Hospital of Philadelphia
RTI International
Nationwide Children’s Hospital
University of Texas Southwestern Medical Center
Brown University
Indiana University Bloomington
The University of Chicago
Case Western Reserve University
University of Missouri at Kansas City
Good Samaritan Hospital Cincinnati

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks’ postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

Original language	English
Pages (from-to)	616-627
Number of pages	12
Journal	Journal of Perinatology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1038/s41372-020-0594-4
State	Published - Apr 1 2020

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10.1038/s41372-020-0594-4

Cite this

@article{477506e212584a41870f83399f7b666a,

title = "Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes",

abstract = "Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks{\textquoteright} postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95\% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95\% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.",

author = "\{for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network\} and Harmon, \{Heidi M.\} and Jensen, \{Erik A.\} and Sylvia Tan and Chaudhary, \{Aasma S.\} and Slaughter, \{Jonathan L.\} and Bell, \{Edward F.\} and Wyckoff, \{Myra H.\} and Hensman, \{Angelita M.\} and Sokol, \{Gregory M.\} and DeMauro, \{Sara B.\} and Caplan, \{Michael S.\} and Laptook, \{Abbott R.\} and Martin Keszler and Vohr, \{Betty R.\} and Barbara Alksninis and Basso, \{Kristin M.\} and Robert Burke and Melinda Caskey and Katharine Johnson and Keszler, \{Mary Lenore\} and Knoll, \{Andrea M.\} and Leach, \{Theresa M.\} and Emilee Little and McGowan, \{Elisabeth C.\} and Elisa Vieira and Watson, \{Victoria E.\} and Suzy Ventura and Walsh, \{Michele C.\} and Hibbs, \{Anna Maria\} and Wilson-Costello, \{Deanne E.\} and Newman, \{Nancy S.\} and Payne, \{Allison H.\} and Siner, \{Bonnie S.\} and Monika Bhola and Gulgun Yalcinkaya and Truog, \{William E.\} and Pallotto, \{Eugenia K.\} and Kilbride, \{Howard W.\} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Allison Scott and Kurt Schibler and Donovan, \{Edward F.\} and Cathy Grisby and Kate Bridges and Barbara Alexander and Fischer, \{Estelle E.\} and Osman Farooq and Reynolds, \{Anne Marie\}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2020",

month = apr,

day = "1",

doi = "10.1038/s41372-020-0594-4",

language = "English",

volume = "40",

pages = "616--627",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Springer Nature",

number = "4",

}

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes. / for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.
In: Journal of Perinatology, Vol. 40, No. 4, 01.04.2020, p. 616-627.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Timing of postnatal steroids for bronchopulmonary dysplasia

T2 - association with pulmonary and neurodevelopmental outcomes

AU - for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

AU - Harmon, Heidi M.

AU - Jensen, Erik A.

AU - Tan, Sylvia

AU - Chaudhary, Aasma S.

AU - Slaughter, Jonathan L.

AU - Bell, Edward F.

AU - Wyckoff, Myra H.

AU - Hensman, Angelita M.

AU - Sokol, Gregory M.

AU - DeMauro, Sara B.

AU - Caplan, Michael S.

AU - Laptook, Abbott R.

AU - Keszler, Martin

AU - Vohr, Betty R.

AU - Alksninis, Barbara

AU - Basso, Kristin M.

AU - Burke, Robert

AU - Caskey, Melinda

AU - Johnson, Katharine

AU - Keszler, Mary Lenore

AU - Knoll, Andrea M.

AU - Leach, Theresa M.

AU - Little, Emilee

AU - McGowan, Elisabeth C.

AU - Vieira, Elisa

AU - Watson, Victoria E.

AU - Ventura, Suzy

AU - Walsh, Michele C.

AU - Hibbs, Anna Maria

AU - Wilson-Costello, Deanne E.

AU - Newman, Nancy S.

AU - Payne, Allison H.

AU - Siner, Bonnie S.

AU - Bhola, Monika

AU - Yalcinkaya, Gulgun

AU - Truog, William E.

AU - Pallotto, Eugenia K.

AU - Kilbride, Howard W.

AU - Gauldin, Cheri

AU - Holmes, Anne

AU - Johnson, Kathy

AU - Scott, Allison

AU - Schibler, Kurt

AU - Donovan, Edward F.

AU - Grisby, Cathy

AU - Bridges, Kate

AU - Alexander, Barbara

AU - Fischer, Estelle E.

AU - Farooq, Osman

AU - Reynolds, Anne Marie

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks’ postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

AB - Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks’ postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

UR - https://www.scopus.com/pages/publications/85079134436

U2 - 10.1038/s41372-020-0594-4

DO - 10.1038/s41372-020-0594-4

M3 - Article

C2 - 32020038

SN - 0743-8346

VL - 40

SP - 616

EP - 627

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 4

ER -

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

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