TiO2 nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium

Jonathan Richter; Gabriella Shull; Gretchen Mahler

doi:10.1109/NEBEC.2015.7117124

TiO₂ nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium

Jonathan Richter
, Gabriella Shull
, Gretchen Mahler

Biomedical Engineering

Binghamton University

State University of New York Binghamton University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

An in vitro model of the small intestinal epithelium was utilized to model changes in glucose transport caused by exposure to 30 nm titanium dioxide nanoparticles. Glucose transport across the intestinal model was significantly lower with exposure to titanium dioxide nanoparticles. In the presence of the beneficial bacterium L. rhamnosus, however, these changes were no longer observed. These results could be significant, as changes in glucose absorption are associated with metabolic syndrome.

Original language	English
Title of host publication	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479983605
DOIs	https://doi.org/10.1109/NEBEC.2015.7117124
State	Published - Jun 2 2015
Event	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015

Publication series

Name	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Conference

Conference	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country/Territory	United States
City	Troy
Period	04/17/15 → 04/19/15

Keywords

Metabolic Disorders
Microbiome
Nanoparticles
Titanium Dioxide

Access to Document

10.1109/NEBEC.2015.7117124

Cite this

Richter, J., Shull, G., & Mahler, G. (2015). TiO₂ nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 Article 7117124 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2015.7117124

Richter, Jonathan ; Shull, Gabriella ; Mahler, Gretchen. / TiO₂ nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium. 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).

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abstract = "An in vitro model of the small intestinal epithelium was utilized to model changes in glucose transport caused by exposure to 30 nm titanium dioxide nanoparticles. Glucose transport across the intestinal model was significantly lower with exposure to titanium dioxide nanoparticles. In the presence of the beneficial bacterium L. rhamnosus, however, these changes were no longer observed. These results could be significant, as changes in glucose absorption are associated with metabolic syndrome.",

keywords = "Metabolic Disorders, Microbiome, Nanoparticles, Titanium Dioxide",

author = "Jonathan Richter and Gabriella Shull and Gretchen Mahler",

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doi = "10.1109/NEBEC.2015.7117124",

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Richter, J, Shull, G & Mahler, G 2015, TiO₂ nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117124, 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 04/17/15. https://doi.org/10.1109/NEBEC.2015.7117124

TiO₂ nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium. / Richter, Jonathan; Shull, Gabriella; Mahler, Gretchen.
2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117124 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Richter, Jonathan

AU - Shull, Gabriella

AU - Mahler, Gretchen

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N2 - An in vitro model of the small intestinal epithelium was utilized to model changes in glucose transport caused by exposure to 30 nm titanium dioxide nanoparticles. Glucose transport across the intestinal model was significantly lower with exposure to titanium dioxide nanoparticles. In the presence of the beneficial bacterium L. rhamnosus, however, these changes were no longer observed. These results could be significant, as changes in glucose absorption are associated with metabolic syndrome.

AB - An in vitro model of the small intestinal epithelium was utilized to model changes in glucose transport caused by exposure to 30 nm titanium dioxide nanoparticles. Glucose transport across the intestinal model was significantly lower with exposure to titanium dioxide nanoparticles. In the presence of the beneficial bacterium L. rhamnosus, however, these changes were no longer observed. These results could be significant, as changes in glucose absorption are associated with metabolic syndrome.

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KW - Microbiome

KW - Nanoparticles

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PB - Institute of Electrical and Electronics Engineers Inc.

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Richter J, Shull G, Mahler G. TiO₂ nanoparticle ingestion alters glucose absorption in an in vitro model of the intestinal epithelium. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7117124. (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). doi: 10.1109/NEBEC.2015.7117124