To kill a tachyzoite: assault and battery

Azadeh Nasuhidehnavi; George S. Yap

doi:10.1016/j.pt.2024.05.002

To kill a tachyzoite: assault and battery

Azadeh Nasuhidehnavi
, George S. Yap

Pharmaceutical Sciences

Binghamton University

Rutgers - The State University of New Jersey, New Brunswick

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.

Original language	English
Pages (from-to)	449-451
Number of pages	3
Journal	Trends in Parasitology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1016/j.pt.2024.05.002
State	Published - Jun 2024

Keywords

GBP
cell autonomous immunity
iNOS
nitrosylation

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10.1016/j.pt.2024.05.002

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title = "To kill a tachyzoite: assault and battery",

abstract = "Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.",

keywords = "GBP, cell autonomous immunity, iNOS, nitrosylation",

author = "Azadeh Nasuhidehnavi and Yap, \{George S.\}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = jun,

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language = "English",

volume = "40",

pages = "449--451",

journal = "Trends in Parasitology",

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T1 - To kill a tachyzoite

T2 - assault and battery

AU - Nasuhidehnavi, Azadeh

AU - Yap, George S.

PY - 2024/6

Y1 - 2024/6

N2 - Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.

AB - Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.

KW - GBP

KW - cell autonomous immunity

KW - iNOS

KW - nitrosylation

UR - https://www.scopus.com/pages/publications/85194172072

U2 - 10.1016/j.pt.2024.05.002

DO - 10.1016/j.pt.2024.05.002

M3 - Short survey

C2 - 38762372

SN - 1471-4922

VL - 40

SP - 449

EP - 451

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 6

ER -

To kill a tachyzoite: assault and battery

Abstract

Keywords

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