@inproceedings{1723e412bd2b4a51a0a1b8daf9e6c7b5,
title = "TopoTxR: A Topological Biomarker for Predicting Treatment Response in Breast Cancer",
abstract = "Characterization of breast parenchyma on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a challenging task owing to the complexity of underlying tissue structures. Current quantitative approaches, including radiomics and deep learning models, do not explicitly capture the complex and subtle parenchymal structures, such as fibroglandular tissue. In this paper, we propose a novel method to direct a neural network{\textquoteright}s attention to a dedicated set of voxels surrounding biologically relevant tissue structures. By extracting multi-dimensional topological structures with high saliency, we build a topology-derived biomarker, TopoTxR. We demonstrate the efficacy of TopoTxR in predicting response to neoadjuvant chemotherapy in breast cancer. Our qualitative and quantitative results suggest differential topological behavior of breast tissue on treatment-na{\"i}ve imaging, in patients who respond favorably to therapy versus those who do not.",
keywords = "Breast cancer, Neoadjuvant chemotherapy, Persistent homology, Topology",
author = "Fan Wang and Saarthak Kapse and Steven Liu and Prateek Prasanna and Chao Chen",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.; 27th International Conference on Information Processing in Medical Imaging, IPMI 2021 ; Conference date: 28-06-2021 Through 30-06-2021",
year = "2021",
doi = "10.1007/978-3-030-78191-0\_30",
language = "English",
isbn = "9783030781903",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "386--397",
editor = "Aasa Feragen and Stefan Sommer and Julia Schnabel and Mads Nielsen",
booktitle = "Information Processing in Medical Imaging - 27th International Conference, IPMI 2021, Proceedings",
}