Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD

William E. Pelham; Lisa Burrows-MacLean; Elizabeth M. Gnagy; Gregory A. Fabiano; Erika K. Coles; Katy E. Tresco; Anil Chacko; Brian T. Wymbs; Amber L. Wienke; Kathryn S. Walker; Martin T. Hoffman

doi:10.1037/1064-1297.13.2.111

Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD

William E. Pelham
, Lisa Burrows-MacLean
, Elizabeth M. Gnagy
, Gregory A. Fabiano
, Erika K. Coles
, Katy E. Tresco
, Anil Chacko
, Brian T. Wymbs
, Amber L. Wienke
, Kathryn S. Walker
, Martin T. Hoffman

Counseling, School and Educational Psychology

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm², 25.0 cm², and 37.5 cm ²). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH-even lower than in previous studies-yielded enhanced effects in combination with behavior modification.

Original language	English
Pages (from-to)	111-126
Number of pages	16
Journal	Experimental and Clinical Psychopharmacology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1037/1064-1297.13.2.111
State	Published - May 2005

Keywords

Attention deficit hyperactivity disorder
Behavioral treatment
Combined treatment
Methylphenidate

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10.1037/1064-1297.13.2.111

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title = "Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD",

abstract = "Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm2, 25.0 cm2, and 37.5 cm 2). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH-even lower than in previous studies-yielded enhanced effects in combination with behavior modification.",

keywords = "Attention deficit hyperactivity disorder, Behavioral treatment, Combined treatment, Methylphenidate",

author = "Pelham, \{William E.\} and Lisa Burrows-MacLean and Gnagy, \{Elizabeth M.\} and Fabiano, \{Gregory A.\} and Coles, \{Erika K.\} and Tresco, \{Katy E.\} and Anil Chacko and Wymbs, \{Brian T.\} and Wienke, \{Amber L.\} and Walker, \{Kathryn S.\} and Hoffman, \{Martin T.\}",

year = "2005",

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AU - Gnagy, Elizabeth M.

AU - Fabiano, Gregory A.

AU - Coles, Erika K.

AU - Tresco, Katy E.

AU - Chacko, Anil

AU - Wymbs, Brian T.

AU - Wienke, Amber L.

AU - Walker, Kathryn S.

AU - Hoffman, Martin T.

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AB - Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm2, 25.0 cm2, and 37.5 cm 2). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH-even lower than in previous studies-yielded enhanced effects in combination with behavior modification.

KW - Attention deficit hyperactivity disorder

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KW - Combined treatment

KW - Methylphenidate

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JO - Experimental and Clinical Psychopharmacology

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Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD

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Keywords

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