Traumatic brain injury therapeutics

Severe traumatic brain injury physiologically is a heterogeneous disorder that is characterized by a cascade of events from the “second-hit” phenomenon. The management of these patients is becoming increasingly sophisticated with the introduction of multimodal monitoring systems and better understanding of the complex interactions of the brain and other vital organs. Many of the traditional therapeutic options still lack level 1 evidence, however, this chapter is focused on the key therapeutic options that significantly impact the outcome of severe TBI patients.