Abstract
Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences.
| Original language | English |
|---|---|
| Pages (from-to) | 12593-12596 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 50 |
| DOIs | |
| State | Published - Dec 7 2012 |
Keywords
- modified nucleobases
- peptide nucleic acids
- sequence-selective RNA recognition
- triple helices
Fingerprint
Dive into the research topics of 'Triple-helical recognition of RNA using 2-aminopyridine-modified PNA at physiologically relevant conditions'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver