Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

Mark F. Cotton; H. S. Schaaf; G. Lottering; H. L. Weber; J. Coetzee; S. Nachman

Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

Mark F. Cotton
, H. S. Schaaf
, G. Lottering
, H. L. Weber
, J. Coetzee
, S. Nachman

Pediatrics

Stony Brook University

Stellenbosch University

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, 95%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure.

Original language	English
Pages (from-to)	225-227
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	12
Issue number	2
State	Published - Feb 2008

Keywords

Drug resistance
HIV-exposed infants
PMTCT
Tuberculosis exposure

Cite this

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title = "Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting",

abstract = "Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1\%, 95\%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure.",

keywords = "Drug resistance, HIV-exposed infants, PMTCT, Tuberculosis exposure",

author = "Cotton, \{Mark F.\} and Schaaf, \{H. S.\} and G. Lottering and Weber, \{H. L.\} and J. Coetzee and S. Nachman",

year = "2008",

month = feb,

language = "English",

volume = "12",

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journal = "International Journal of Tuberculosis and Lung Disease",

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T1 - Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

AU - Cotton, Mark F.

AU - Schaaf, H. S.

AU - Lottering, G.

AU - Weber, H. L.

AU - Coetzee, J.

AU - Nachman, S.

PY - 2008/2

Y1 - 2008/2

N2 - Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, 95%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure.

AB - Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, 95%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure.

KW - Drug resistance

KW - HIV-exposed infants

KW - PMTCT

KW - Tuberculosis exposure

UR - https://www.scopus.com/pages/publications/38949172727

M3 - Article

C2 - 18230259

SN - 1027-3719

VL - 12

SP - 225

EP - 227

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 2

ER -

Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

Abstract

Keywords

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