Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches

J. Domingo Sánchez; Jorge Gómez-Carpintero; Juan F. González; J. Carlos Menéndez

doi:10.1016/j.ejmech.2024.116476

Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches

J. Domingo Sánchez
, Jorge Gómez-Carpintero
, Juan F. González
, J. Carlos Menéndez

Geriatric and General Medicine

Stony Brook University

Complutense University

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

The therapeutic use of the traditional drugs against epilepsy has been hindered by their toxicity and low selectivity. These limitations have stimulated the design and development of new generations of antiepileptic drugs. This review explores the molecular targets and synthesis of the antiepileptic drugs that have entered the market in the 21st century, with a focus on manufacturer synthesis.

Original language	English
Article number	116476
Journal	European Journal of Medicinal Chemistry
Volume	272
DOIs	https://doi.org/10.1016/j.ejmech.2024.116476
State	Published - Jun 5 2024

Keywords

Antiepileptic targets
Drug synthesis
Heterocycles
Neurosteroids
Peptidomimetics

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10.1016/j.ejmech.2024.116476

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abstract = "The therapeutic use of the traditional drugs against epilepsy has been hindered by their toxicity and low selectivity. These limitations have stimulated the design and development of new generations of antiepileptic drugs. This review explores the molecular targets and synthesis of the antiepileptic drugs that have entered the market in the 21st century, with a focus on manufacturer synthesis.",

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AU - Gómez-Carpintero, Jorge

AU - González, Juan F.

AU - Menéndez, J. Carlos

PY - 2024/6/5

Y1 - 2024/6/5

N2 - The therapeutic use of the traditional drugs against epilepsy has been hindered by their toxicity and low selectivity. These limitations have stimulated the design and development of new generations of antiepileptic drugs. This review explores the molecular targets and synthesis of the antiepileptic drugs that have entered the market in the 21st century, with a focus on manufacturer synthesis.

AB - The therapeutic use of the traditional drugs against epilepsy has been hindered by their toxicity and low selectivity. These limitations have stimulated the design and development of new generations of antiepileptic drugs. This review explores the molecular targets and synthesis of the antiepileptic drugs that have entered the market in the 21st century, with a focus on manufacturer synthesis.

KW - Antiepileptic targets

KW - Drug synthesis

KW - Heterocycles

KW - Neurosteroids

KW - Peptidomimetics

UR - https://www.scopus.com/pages/publications/85193211212

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DO - 10.1016/j.ejmech.2024.116476

M3 - Review article

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JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 116476

ER -

Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches

Abstract

Keywords

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