Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology

Takashi Yamazaki; Takeo Taguchi; Iwao Ojima

doi:10.1002/9781444312096.ch1

Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology

Takashi Yamazaki
, Takeo Taguchi
, Iwao Ojima

Chemistry

Stony Brook University

Tokyo University of Agriculture and Technology
Tokyo University of Pharmacy and Life Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

138 Scopus citations

Original language	English
Title of host publication	Fluorine in Medicinal Chemistry and Chemical Biology
Publisher	John Wiley & Sons, Ltd
Pages	1-46
Number of pages	46
ISBN (Print)	9781405167208
DOIs	https://doi.org/10.1002/9781444312096.ch1
State	Published - Apr 21 2009

Keywords

Fluorine in medicinal chemistry and chemical biology
High electrophilicity of fluoroalkyl carbonyl moieties
Huge successes of fluorine-containing drugs - stimulating research on fluorine in medicinal chemistry for drug discovery
In vivo 19 F magnetic resonance spectroscopy
Inductive effect of fluorine and fluorine-containing groups
Mimic effect and block effect
Orthogonal multipolar C-F bond-protein interactions
Two fluorine-containing drugs
Unique properties of fluorine and their relevance

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10.1002/9781444312096.ch1

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title = "Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology",

keywords = "Fluorine in medicinal chemistry and chemical biology, High electrophilicity of fluoroalkyl carbonyl moieties, Huge successes of fluorine-containing drugs - stimulating research on fluorine in medicinal chemistry for drug discovery, In vivo 19 F magnetic resonance spectroscopy, Inductive effect of fluorine and fluorine-containing groups, Mimic effect and block effect, Orthogonal multipolar C-F bond-protein interactions, Two fluorine-containing drugs, Unique properties of fluorine and their relevance",

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T1 - Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology

AU - Yamazaki, Takashi

AU - Taguchi, Takeo

AU - Ojima, Iwao

PY - 2009/4/21

Y1 - 2009/4/21

KW - Fluorine in medicinal chemistry and chemical biology

KW - High electrophilicity of fluoroalkyl carbonyl moieties

KW - Huge successes of fluorine-containing drugs - stimulating research on fluorine in medicinal chemistry for drug discovery

KW - In vivo 19 F magnetic resonance spectroscopy

KW - Inductive effect of fluorine and fluorine-containing groups

KW - Mimic effect and block effect

KW - Orthogonal multipolar C-F bond-protein interactions

KW - Two fluorine-containing drugs

KW - Unique properties of fluorine and their relevance

UR - https://www.scopus.com/pages/publications/84889483761

U2 - 10.1002/9781444312096.ch1

DO - 10.1002/9781444312096.ch1

M3 - Chapter

SN - 9781405167208

SP - 1

EP - 46

BT - Fluorine in Medicinal Chemistry and Chemical Biology

PB - John Wiley & Sons, Ltd

ER -

Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology

Keywords

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