Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

Eugene H. Herman; Steven E. Lipshultz; Nader Rifai; Jun Zhang; Thomas Papoian; Zu Xi Yu; Kazuyo Takeda; Victor J. Ferrans

Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

Eugene H. Herman
, Steven E. Lipshultz
, Nader Rifai
, Jun Zhang
, Thomas Papoian
, Zu Xi Yu
, Kazuyo Takeda
, Victor J. Ferrans

Pediatrics

University at Buffalo

United States Food and Drug Administration
Boston Children's Hospital
National Institutes of Health

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin- induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were fUrther elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.

Original language	English
Pages (from-to)	195-197
Number of pages	3
Journal	Cancer Research
Volume	58
Issue number	2
State	Published - Jan 15 1998

Cite this

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title = "Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity",

abstract = "The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin- induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were fUrther elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.",

author = "Herman, \{Eugene H.\} and Lipshultz, \{Steven E.\} and Nader Rifai and Jun Zhang and Thomas Papoian and Yu, \{Zu Xi\} and Kazuyo Takeda and Ferrans, \{Victor J.\}",

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T1 - Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

AU - Herman, Eugene H.

AU - Lipshultz, Steven E.

AU - Rifai, Nader

AU - Zhang, Jun

AU - Papoian, Thomas

AU - Yu, Zu Xi

AU - Takeda, Kazuyo

AU - Ferrans, Victor J.

PY - 1998/1/15

Y1 - 1998/1/15

N2 - The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin- induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were fUrther elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.

AB - The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin- induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were fUrther elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.

UR - https://www.scopus.com/pages/publications/0031974196

M3 - Article

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SN - 0008-5472

VL - 58

SP - 195

EP - 197

JO - Cancer Research

JF - Cancer Research

IS - 2

ER -

Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

Abstract

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