Use of primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients

Anjali Kewalramani; Shaurya Sharma; Katrina Sandejas; Daniel Rampersad; Qu Zhong; Briana Episcopia; Leon Boudourakis; John Quale

doi:10.1017/ash.2025.10095

Use of primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients

Anjali Kewalramani
, Shaurya Sharma
, Katrina Sandejas
, Daniel Rampersad
, Qu Zhong
, Briana Episcopia
, Leon Boudourakis
, John Quale

Medicine

SUNY Downstate Health Sciences University

New York City Health and Hospitals Corporation

Research output: Contribution to journal › Article › peer-review

Abstract

Over 5.5-months, hospital-onset Clostridioides difficile infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days (P =.03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days (P =.05). Primary OVP curbed an outbreak of HO-CDI.

Original language	English
Article number	e224
Journal	Antimicrobial Stewardship and Healthcare Epidemiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1017/ash.2025.10095
State	Published - Sep 18 2025

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abstract = "Over 5.5-months, hospital-onset Clostridioides difficile infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days (P =.03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days (P =.05). Primary OVP curbed an outbreak of HO-CDI.",

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AU - Kewalramani, Anjali

AU - Sharma, Shaurya

AU - Sandejas, Katrina

AU - Rampersad, Daniel

AU - Zhong, Qu

AU - Episcopia, Briana

AU - Boudourakis, Leon

AU - Quale, John

PY - 2025/9/18

Y1 - 2025/9/18

N2 - Over 5.5-months, hospital-onset Clostridioides difficile infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days (P =.03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days (P =.05). Primary OVP curbed an outbreak of HO-CDI.

AB - Over 5.5-months, hospital-onset Clostridioides difficile infections (HO-CDI) in intensive care units (ICUs) increased from a baseline 6.2 cases to 19.1 cases per 10,000 patient-days (P =.03). Primary oral vancomycin prophylaxis (OVP) to select patients was initiated; subsequently there were 5.7 cases /10,000 patient-days (P =.05). Primary OVP curbed an outbreak of HO-CDI.

UR - https://www.scopus.com/pages/publications/105016795301

U2 - 10.1017/ash.2025.10095

DO - 10.1017/ash.2025.10095

M3 - Article

SN - 2732-494X

VL - 5

JO - Antimicrobial Stewardship and Healthcare Epidemiology

JF - Antimicrobial Stewardship and Healthcare Epidemiology

IS - 1

M1 - e224

ER -

Use of primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients

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