Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension

Alan H. Lockwood; Eddy W.H. Yap

doi:10.1007/BF01000380

Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension

Alan H. Lockwood
, Eddy W.H. Yap

Neurology

University at Buffalo

University of Texas Health Science Center at Houston

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Carotid ligation and moderate hypoxia in rats causes an increase in the glucose metabolic rate in the caudate-putamen and more widespread reductions in pH. Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis. These data suggest that calcium channel blockade may protect the brain from injury during hypoxic hypoxia by preventing the development of acidosis.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Metabolic Brain Disease
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/BF01000380
State	Published - Mar 1991

Keywords

brain metabolism
calcium channel blockade
hypoxia
quantitative autoradiography

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10.1007/BF01000380

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title = "Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension",

abstract = "Carotid ligation and moderate hypoxia in rats causes an increase in the glucose metabolic rate in the caudate-putamen and more widespread reductions in pH. Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis. These data suggest that calcium channel blockade may protect the brain from injury during hypoxic hypoxia by preventing the development of acidosis.",

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year = "1991",

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AU - Lockwood, Alan H.

AU - Yap, Eddy W.H.

PY - 1991/3

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N2 - Carotid ligation and moderate hypoxia in rats causes an increase in the glucose metabolic rate in the caudate-putamen and more widespread reductions in pH. Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis. These data suggest that calcium channel blockade may protect the brain from injury during hypoxic hypoxia by preventing the development of acidosis.

AB - Carotid ligation and moderate hypoxia in rats causes an increase in the glucose metabolic rate in the caudate-putamen and more widespread reductions in pH. Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis. These data suggest that calcium channel blockade may protect the brain from injury during hypoxic hypoxia by preventing the development of acidosis.

KW - brain metabolism

KW - calcium channel blockade

KW - hypoxia

KW - quantitative autoradiography

UR - https://www.scopus.com/pages/publications/0025778587

U2 - 10.1007/BF01000380

DO - 10.1007/BF01000380

M3 - Article

C2 - 1857324

SN - 0885-7490

VL - 6

SP - 1

EP - 5

JO - Metabolic Brain Disease

JF - Metabolic Brain Disease

IS - 1

ER -

Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension

Abstract

Keywords

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