Viral proteases as targets for chemotherapeutic intervention

Christopher U.T. Hellen; Eckard Wimmer

doi:10.1016/0958-1669(92)90010-G

Viral proteases as targets for chemotherapeutic intervention

Christopher U.T. Hellen
, Eckard Wimmer

Cell / Cellular Biology and Anatomical Sciences

SUNY Downstate Health Sciences University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases.

Original language	English
Pages (from-to)	643-649
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/0958-1669(92)90010-G
State	Published - Dec 1992

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title = "Viral proteases as targets for chemotherapeutic intervention",

abstract = "Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases.",

author = "Hellen, \{Christopher U.T.\} and Eckard Wimmer",

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T1 - Viral proteases as targets for chemotherapeutic intervention

AU - Hellen, Christopher U.T.

AU - Wimmer, Eckard

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N2 - Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases.

AB - Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases.

UR - https://www.scopus.com/pages/publications/0027034146

U2 - 10.1016/0958-1669(92)90010-G

DO - 10.1016/0958-1669(92)90010-G

M3 - Article

C2 - 1369416

SN - 0958-1669

VL - 3

SP - 643

EP - 649

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 6

ER -

Viral proteases as targets for chemotherapeutic intervention

Abstract

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