Yao syndrome: A potential role and association of vasoactive intestinal peptide with NOD2

Brianne Navetta-Modrov; Berhane Ghebrehiwet; Qingping Yao

doi:10.2478/rir-2021-0005

Yao syndrome: A potential role and association of vasoactive intestinal peptide with NOD2

Allergy and Immunology

Stony Brook University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.

Original language	English
Pages (from-to)	57-59
Number of pages	3
Journal	Rheumatology and Immunology Research
Volume	2
Issue number	1
DOIs	https://doi.org/10.2478/rir-2021-0005
State	Published - Mar 1 2021

Keywords

NOD2
NOD2-associated autoinflammatory disease
Yao syndrome
rash
vasoactive intestinal peptide

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abstract = "Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.",

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author = "Brianne Navetta-Modrov and Berhane Ghebrehiwet and Qingping Yao",

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AU - Ghebrehiwet, Berhane

AU - Yao, Qingping

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AB - Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.

KW - NOD2

KW - NOD2-associated autoinflammatory disease

KW - Yao syndrome

KW - rash

KW - vasoactive intestinal peptide

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JO - Rheumatology and Immunology Research

JF - Rheumatology and Immunology Research

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Yao syndrome: A potential role and association of vasoactive intestinal peptide with NOD2

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