Yeast viral RNA polymerase is a transcriptase

Jeremy Bruenn; Libuse Bobek; Victoria Brennan; William Held

doi:10.1093/nar/8.13.2985

Yeast viral RNA polymerase is a transcriptase

Jeremy Bruenn
, Libuse Bobek
, Victoria Brennan
, William Held

Biological Sciences

University at Buffalo

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

ScV-L is a simple double-stranded RNA virus of yeast, consisting of a 4.8 kilobase pair double-stranded RNA (L) encapsidated in isometric particles composed mainly of one polypeptide (ScV-Pl) of 88,000 daltons. L encodes ScV-Pl. There is a capsid-associated RNA polymerase that synthesizes in vitro predominantly single-stranded RNA. We show that this polymerase activity is a transcriptase, at least one product of which is the mRNA for ScV-Pl. The transcript, like its template, is uncapped.

Original language	English
Pages (from-to)	2985-2998
Number of pages	14
Journal	Nucleic Acids Research
Volume	8
Issue number	13
DOIs	https://doi.org/10.1093/nar/8.13.2985
State	Published - Jul 11 1980

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AU - Held, William

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N2 - ScV-L is a simple double-stranded RNA virus of yeast, consisting of a 4.8 kilobase pair double-stranded RNA (L) encapsidated in isometric particles composed mainly of one polypeptide (ScV-Pl) of 88,000 daltons. L encodes ScV-Pl. There is a capsid-associated RNA polymerase that synthesizes in vitro predominantly single-stranded RNA. We show that this polymerase activity is a transcriptase, at least one product of which is the mRNA for ScV-Pl. The transcript, like its template, is uncapped.

AB - ScV-L is a simple double-stranded RNA virus of yeast, consisting of a 4.8 kilobase pair double-stranded RNA (L) encapsidated in isometric particles composed mainly of one polypeptide (ScV-Pl) of 88,000 daltons. L encodes ScV-Pl. There is a capsid-associated RNA polymerase that synthesizes in vitro predominantly single-stranded RNA. We show that this polymerase activity is a transcriptase, at least one product of which is the mRNA for ScV-Pl. The transcript, like its template, is uncapped.

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DO - 10.1093/nar/8.13.2985

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Yeast viral RNA polymerase is a transcriptase

Abstract

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